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A General Approach to Quaternary Center Construction from Couplings of Unactivated Alkenes and Acyl Xanthates
Ernest N Jenkins1, William L Czaplyski1, Erik J Alexanian1
1Department of Chemistry, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
Organic Letters
|April 14, 2017
Abstract:
A general, radical-mediated approach to quaternary center construction using unactivated alkenes as coupling partners is reported. In this strategy, acyl xanthates, readily accessed from carboxylic acids, serve as precursors to tertiary radicals. This strategy leverages the unique reactivity of xanthates to participate in efficient radical-mediated additions to unactivated alkenes, expanding the scope of quaternary center construction.