[Protein level and Na,K-ATPase activity of rat kidney tissues following cis-platin administration]

Concentrations of protein and electrolytes as well as activity of Na,K-ATPase were studied in renal tissue of rats within 5 days after cisplatinum administration (5 mg/kg of body mass, intraperitoneally). There were a significant reduction in the ATPase activity and an increase in water content and sodium concentration in renal cortex tissue, while K+, Ca2+ and Mg2+ were unaltered. At the same time, concentration of electrolytes did not shift in blood serum and muscle tissue. After intraperitoneal administration of choline chloride at a dose of 290 mg/kg of body mass within 40 min before the cisplatinum treatment less distinct alterations were observed in the urea content and in the Na,K-ATPase activity.