Related Experiment Video

Updated: Jul 31, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

[A preliminary study of renal function in small-for-gestational-age infants at early stage after birth]

Jing Zhu1, Yan Xing, Xin-Li Wang

  • 1Department of Pediatrics, Peking University Third Hospital, Beijing 100191, China. xingyan770424@vip.sina.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|April 15, 2017
PubMed

Insights

Early renal function in small-for-gestational-age (SGA) infants differs by gestational age. Full-term SGA infants show impaired renal function, indicated by higher serum creatinine and lower estimated glomerular filtration rate compared to appropriate-for-gestational-age infants.

Area of Science:

  • Neonatal Medicine
  • Pediatric Nephrology
  • Perinatal Research

Background:

  • Small-for-gestational-age (SGA) infants are at risk for various health issues.
  • Early assessment of renal function is crucial for SGA infants.
  • Gestational age may influence renal outcomes in SGA infants.

Purpose of the Study:

  • To evaluate and compare the early renal function of small-for-gestational-age (SGA) infants versus appropriate-for-gestational-age (AGA) infants.
  • To investigate the impact of gestational age (preterm vs. full-term) on renal function in SGA infants.

Main Methods:

  • Compared renal function indices including BUN, SCr, eGFR, blood pressure, urine output, and proteinuria.
  • Included 40 preterm SGA, 33 full-term SGA, 80 preterm AGA, and 33 full-term AGA infants.
  • Analyses were conducted within 48 hours of admission.

Main Results:

  • Preterm SGA infants showed lower BUN than preterm AGA infants.
  • Full-term SGA infants exhibited higher SCr and lower eGFR compared to full-term AGA infants.
  • No significant differences in urine output or proteinuria incidence were observed between SGA and AGA groups within preterm or full-term categories.

Conclusions:

  • Serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) are valuable indicators for detecting early renal damage in SGA infants.
  • Full-term SGA infants demonstrate poorer renal function compared to their full-term AGA counterparts.
  • Early renal function assessment is vital for managing SGA infants.
Abstract

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

Transdermal Measurement of Glomerular Filtration Rate in Mechanically Ventilated Piglets07:41

Transdermal Measurement of Glomerular Filtration Rate in Mechanically Ventilated Piglets

Published on: September 13, 2022

Related Concept Videos

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...