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Changes in bronchial response after Sendai virus infection in guinea pigs
Y Ohashi1, S Motojima, K Yamanouchi
1Department of Medicine and Clinical Immunology, Dokkyo University School of Medicine, Tochigi, Japan.
Annals of Allergy
|August 1, 1988
Abstract:
Enhanced bronchial reactivity to inhaled histamine was observed in guinea pigs infected with Sendai virus with concomitant decrease of beta-adrenergic receptor density in the pulmonary parenchyma 2 to 3 weeks after the inoculation. Histologic examination of the bronchi showed shedding of epithelial cells with a marked infiltration of mononuclear cells. These observations suggest that damage of the bronchial epithelium and decreased density of beta-adrenergic receptor may be the causes of observed bronchial reactivity.