Symmetry Does not Come for Free: Cellular Mechanisms to Achieve a Symmetric Cell Division

During mitosis cells can divide symmetrically to proliferate or asymmetrically to generate tissue diversity. While the mechanisms that ensure asymmetric cell division have been extensively studied, it is often assumed that a symmetric cell division is the default outcome of mitosis. Recent studies, however, imply that the symmetric nature of cell division is actively controlled, as they reveal numerous mechanisms that ensure the formation of equal-sized daughter cells as cells progress through cell division. Here we review our current knowledge of these mechanisms and highlight possible key questions in the field.