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Immunohistochemical analysis of soft tissue sarcomas. Comparisons with electron microscopy
M R Wick1, P E Swanson, J C Manivel
1Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis.
Applied Pathology
|January 1, 1988
Summary
Immunohistochemistry and electron microscopy aid pathologists in diagnosing challenging soft tissue sarcomas. These methods help resolve diagnostic confusion caused by diverse tumor cell differentiation and overlapping microscopic features.
Area of Science:
- Surgical Pathology
- Oncology
- Diagnostic Pathology
Background:
- Soft tissue sarcomas present diagnostic challenges due to diverse differentiation.
- Histologic appearances of these tumors can overlap, leading to pathologist confusion.
Purpose of the Study:
- To summarize the utility of immunohistochemical studies and electron microscopy.
- To resolve diagnostic bewilderment in soft tissue sarcoma cases.
Main Methods:
- Review of immunohistochemical studies.
- Review of electron microscopy findings.
- Application to the spectrum of malignant soft tissue neoplasms.
Main Results:
- Immunohistochemistry effectively resolves diagnostic confusion in many soft tissue sarcoma cases.
- Electron microscopy also plays a useful role in the diagnostic process.
Conclusions:
- Immunohistochemistry and electron microscopy are valuable adjuvant modalities for diagnosing soft tissue sarcomas.
- These techniques aid in clarifying diagnoses of malignant soft tissue neoplasms.