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Related Experiment Videos

Combination therapy in combating cancer.

Reza Bayat Mokhtari1,2,3, Tina S Homayouni1, Narges Baluch4

  • 1Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Oncotarget
|April 15, 2017
PubMed
Summary
This summary is machine-generated.

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Combination therapy, using multiple drugs, improves cancer treatment efficacy and reduces resistance. Repurposing existing drugs offers a cost-effective strategy for developing novel cancer therapies.

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Discovery

Background:

  • Combination therapy is crucial in cancer treatment, enhancing efficacy over monotherapy by targeting multiple pathways.
  • Developing new anti-cancer drugs is costly and time-consuming, necessitating innovative strategies.

Purpose of the Study:

  • To review key pathways targeted in cancer therapy.
  • To discuss repurposed and primary anti-cancer agents gaining traction in research since 2012.

Main Methods:

  • Systematic review of scientific literature.
  • Analysis of combination therapy strategies, including drug repurposing.
  • Focus on agents and pathways relevant to cancer treatment.

Main Results:

Keywords:
HIF-1alphaNrf2-Keap1carbonic anhydrase 9 (CAIX)carbonic anhydrase inhibitor (CAI)histone deacetylase inhibitor (HDACi)

Related Experiment Videos

  • Combination therapy offers synergistic or additive anti-cancer effects, reducing tumor growth and metastasis.
  • Drug repurposing presents a cost-effective approach, leveraging FDA-approved agents for cancer treatment.

    • Conclusions:

    • Combination therapy, especially with repurposed drugs, shows promise for effective and affordable cancer treatment.
    • This approach can mitigate tumor burden and improve outcomes for underserved populations.