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Related Experiment Videos

Early-Onset Alzheimer Disease.

Mario F Mendez1

  • 1Behavioral Neurology Program, David Geffen School of Medicine at UCLA, 300 Westwood Plaza, Suite B-200, Box 956975, Los Angeles, CA 90095, USA; Neurobehavior Unit, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Building 206, Los Angeles, CA 90073, USA.

Neurologic Clinics
|April 16, 2017
PubMed
Summary

Early-onset Alzheimer disease (EOAD) presents unique challenges, including diagnostic delays and varied symptoms. Management requires tailored cognitive support and age-appropriate psychosocial care for younger patients.

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Area of Science:

  • Neurology
  • Geriatrics
  • Neuroscience

Background:

  • Early-onset Alzheimer disease (EOAD) affects individuals under 65, differing from late-onset AD (LOAD).
  • EOAD accounts for approximately 5% of all Alzheimer disease cases.
  • EOAD diagnosis is often delayed and characterized by an aggressive disease course.

Purpose of the Study:

  • To highlight the distinct characteristics of EOAD compared to LOAD.
  • To address the diagnostic challenges and specific needs of EOAD patients.
  • To emphasize the importance of tailored management strategies for EOAD.

Main Methods:

  • Review of existing literature on early-onset Alzheimer disease.
  • Comparative analysis of EOAD and LOAD clinical presentations.
Keywords:
Alzheimer diseaseDementiaEarly-onset dementiaLogopenic variant primary progressive aphasiaProgressive cortical atrophyYoung-onset dementia

Related Experiment Videos

  • Examination of management guidelines for Alzheimer disease.

    • Main Results:

    • EOAD presents with significant differences from LOAD, including atypical cognitive presentations in a substantial percentage of cases.
    • Patients with EOAD experience diagnostic delays and require specific age-related psychosocial support.
    • The aggressive nature of EOAD necessitates focused therapeutic interventions.

    Conclusions:

    • EOAD management parallels LOAD but demands specific attention to targeted cognitive deficits.
    • Age-appropriate psychosocial support and education are crucial for EOAD patients.
    • Recognizing phenotypic variants is key to timely and effective EOAD diagnosis and care.