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Technique for Intranasal Administration of α-Synuclein Aggregates
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Lewy Body Disorders.

Douglas Galasko1

  • 1Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0948, USA.

Neurologic Clinics
|April 16, 2017
PubMed
Summary
This summary is machine-generated.

Dementia with Lewy bodies (DLB) and Parkinson disease with dementia (PDD) are linked by alpha-synuclein protein aggregates. These underdiagnosed conditions affect cognition, movement, and autonomic function, with current treatments offering symptomatic relief.

Keywords:
DementiaDiagnosisLewy bodyManagementα-synuclein

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Area of Science:

  • Neurology
  • Neuroscience
  • Pathology

Background:

  • Dementia syndromes associated with Lewy bodies include dementia with Lewy bodies (DLB) and Parkinson disease with dementia (PDD).
  • DLB is an underdiagnosed cause of dementia in the elderly.
  • PDD involves cognitive impairment in individuals with diagnosed Parkinson disease.

Purpose of the Study:

  • To summarize the neuropathologic substrates, clinical features, diagnostic criteria, and treatment of DLB and PDD.

Main Methods:

  • Review of neuropathologic findings, clinical presentations, and diagnostic criteria for DLB and PDD.

Main Results:

  • Neuropathologic hallmark is widespread alpha-synuclein aggregates in cortical neurons, often with co-existing Alzheimer pathology.
  • Clinical features encompass distinct changes in cognition, behavior, movement, sleep, and autonomic function.
  • Diagnostic criteria integrate these clinical features.

Conclusions:

  • DLB and PDD are distinct but related dementia syndromes characterized by alpha-synuclein pathology.
  • Accurate diagnosis relies on recognizing a constellation of clinical features.
  • Current therapeutic strategies for DLB and PDD are primarily symptomatic.