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Frontotemporal Dementia.

Nicholas T Olney1, Salvatore Spina1, Bruce L Miller2

  • 1Department of Neurology, UCSF Memory and Aging Center, San Francisco, CA, USA.

Neurologic Clinics
|April 16, 2017
PubMed
Summary
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Frontotemporal dementia (FTD) is a diverse brain disorder affecting behavior, language, and motor skills. This review covers FTD

Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Medicine

Background:

  • Frontotemporal dementia (FTD) is a complex neurodegenerative disorder.
  • It presents with varied clinical symptoms and underlying pathologies.

Observation:

  • FTD spectrum includes behavioral variant FTD, primary progressive aphasias (nonfluent/agrammatic and semantic variants).
  • Related conditions include FTD with motor neuron disease, progressive supranuclear palsy, and corticobasal syndrome.

Findings:

  • This article reviews the clinical presentations of core and related FTD disorders.
  • Diagnostic criteria, neuropathology, genetic factors, and therapeutic strategies are discussed.

Implications:

  • Understanding FTD heterogeneity is crucial for accurate diagnosis and management.
Keywords:
Corticobasal syndrome (CBS)Frontotemporal dementia (FTD)Motor neuron diseaseNonfluent PPAPrimary progressive aphasiaProgressive supranuclear palsy (PSP)Semantic PPA

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  • Further research into neuropathology and genetics can guide treatment development.