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Treatment outcome of extrapulmonary tuberculosis under Revised National Tuberculosis Control Programme
J J Cherian1, I Lobo2, A Sukhlecha3
1Department of Pharmacology, Government Medical College, Trivandrum 695011, Kerala, India.
The Indian Journal of Tuberculosis
|April 16, 2017
Summary
Extrapulmonary tuberculosis (EPTB) treatment completion rates varied by site and HIV status. Central nervous system (CNS) tuberculosis and HIV-positive patients had poorer outcomes, necessitating targeted interventions.
Area of Science:
- Public Health
- Infectious Diseases
- Clinical Medicine
Background:
- Extrapulmonary tuberculosis (EPTB) accounts for 15-20% of tuberculosis cases in India.
- Limited data exists on treatment outcomes for individual EPTB sites.
Purpose of the Study:
- To evaluate the treatment outcomes of EPTB across different organ systems.
- To assess the effectiveness of Directly Observed Treatment Short course (DOTS) under the Revised National Tuberculosis Control Programme for EPTB.
Main Methods:
- A multi-centric retrospective review of TB registers was conducted across three Indian states.
- Data from 2219 EPTB patients were analyzed.
Main Results:
- Lymph node (34.4%) and pleural effusion (25.2%) were the most common EPTB sites.
- Overall treatment completion was 84%, but lower in HIV-positive (66%) and CNS tuberculosis patients (63.7%).
- Treatment completion rates varied significantly by site, with genitourinary (92.6%) and lymph node (90.9%) having higher rates.
Conclusions:
- HIV infection and CNS involvement are associated with poor EPTB treatment outcomes.
- Improved strategies are crucial to enhance treatment completion rates in vulnerable EPTB patient groups.
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