Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enriched environment effects on remote object recognition memory.

Riccardo Melani1, Gabriele Chelini2, Maria Cristina Cenni1

  • 1Institute of Neuroscience of the National Research Council of Italy, 56124 Pisa, Italy.

Neuroscience
|April 17, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined physical and cognitive training enhances telomere length in mild cognitive impairment patients.

BMC geriatrics·2026
Same author

Phenotypic and functional heterogeneity of naïve CD8<sup>+</sup> T cells in human peripheral blood during aging.

Frontiers in aging·2026
Same author

Astaxanthin improves behavioural and immune dysfunction in the Shank3b mouse model of autism spectrum disorder.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Subsecond dopamine fluctuations do not specify the vigor of ongoing actions.

Nature neuroscience·2025
Same author

Spontaneous activity of astrocytes is a stochastic functional signal for memory consolidation.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

A Journey between Neurons and Astrocytes: A Tribute to Giorgio Carmignoto.

Neurochemical research·2025

Environmental enrichment (EE) enhances long-term memory in mice, improving object recognition and extending the window for memory saving. EE mice demonstrated better memory recall and benefited more from retraining than standard condition mice.

Area of Science:

  • Neuroscience
  • Memory Research
  • Animal Behavior

Background:

  • Declarative memories undergo a time-dependent loss, progressing from irretrievability to extinction.
  • Environmental enrichment (EE) is known to improve learning and memory consolidation.
  • The impact of EE on the time-dependent trajectory of memory decay remains unexplored.

Purpose of the Study:

  • To investigate whether environmental enrichment (EE) influences the time-dependent process of memory oblivion.
  • To assess the effect of EE on long-term object recognition memory retrieval in mice.

Main Methods:

  • Adult mice were subjected to either environmental enrichment (EE) or standard conditions (SC) for 40 days.
  • Object Recognition Test (ORT) was used to evaluate memory retrieval at 9 and 21 days post-learning.
Keywords:
brain activationenriched environmentlong-term memoryobject recognitionsaving effect

Related Experiment Videos

  • Memory retrieval was assessed with and without a retraining session prior to testing.

    • Main Results:

    • EE mice showed spontaneous object recognition memory at day 9, unlike SC mice who required retraining.
    • At day 21, EE mice still benefited from retraining, whereas SC mice did not show significant memory retrieval.
    • Brain activity patterns (c-fos expression) differed between EE and SC mice post-retraining, suggesting distinct memory trace utilization.

    Conclusions:

    • Environmental enrichment promotes the formation of more durable object recognition memories.
    • EE extends the time window during which memory saving effects can be observed.
    • EE may facilitate a more robust and prolonged memory consolidation process.