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Regulation of Innate and Adaptive Immunity by TGFβ.

Aoife Kelly1, Stephanie A Houston1, Eleanor Sherwood1

  • 1Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom; Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester, United Kingdom; Manchester Immunology Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Advances in Immunology
|April 18, 2017
PubMed
Summary
This summary is machine-generated.

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Transforming growth factor beta (TGFβ) is a vital cytokine regulating immune homeostasis and responses. This review highlights TGFβ

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Cytokines are critical for immune homeostasis, infection response, inflammation resolution, and memory.
  • Cytokine dysregulation contributes to immune-mediated diseases.
  • Transforming growth factor beta (TGFβ) is a key cytokine influencing immune responses.

Purpose of the Study:

  • To review the multifaceted roles of TGFβ in regulating the immune system.
  • To highlight the context-dependent functions of TGFβ in immune regulation.

Main Methods:

  • Literature review of studies on TGFβ and immune cell function.
  • Analysis of TGFβ's regulatory mechanisms across different immune cell types.

Main Results:

Keywords:
B cellDendritic cellEosinophilInnate lymphoid cellMast cellNK cellNeutrophilRegulatory T cellT cellTGFβTransforming growth factor beta

Related Experiment Videos

  • TGFβ regulates virtually all innate and adaptive immune cells, including T cells, dendritic cells, B cells, NK cells, innate lymphoid cells, and granulocytes.
  • TGFβ's functions are diverse and vary based on its location and the specific cellular context.

Conclusions:

  • TGFβ is a pleiotropic cytokine essential for immune regulation.
  • Understanding TGFβ's context-specific actions is crucial for managing immune responses and diseases.