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Wnt Signaling and Colorectal Cancer
Emma M Schatoff1,2, Benjamin I Leach1,3, Lukas E Dow1,4,5
1Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, 10021.
Current Colorectal Cancer Reports
|April 18, 2017
Abstract:
The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of the WNT pathway, which in many cases is believed to be the initiating and driving event. In this short review, we provide a focused overview of recent developments in our understanding of the WNT pathway in CRC, describe new research tools that are enabling a deeper understanding of WNT biology, and outline ongoing efforts to target this pathway therapeutically.