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Short-term Effects of Radioiodine Therapy on Auditory Function
Deniz Tuna Edizer1, Suat Bilici1, Muhammet Yıldız1
1Clinic of Otorhinolaryngology, İstanbul Training and Research Hospital, İstanbul, Turkey.
Objective:
Radioiodine therapy (RIT) is frequently utilized as an adjunctive treatment option for differentiated thyroid carcinoma following surgical intervention. The side effects of RIT are considered to emerge as a result of radioiodine accumulation in non-thyroidal tissues capable of iodine uptake. We aimed to evaluate the effects of RIT on auditory function.
Materials And Methods:
Patients who had undergone total thyroidectomy and diagnosed to have differentiated thyroid carcinoma were analyzed. Those who were given RIT were included. Pure-tone audiometry and distortion product otoacoustic emission (DP-OAE) results were recorded along with patient demographics, RIT dose, and thyroid hormone profiles, both before and 3 months after RIT.
Results:
Here, 63 patients were enrolled. Following RIT, audiometric thresholds at 0.25, 0.5, 4, and 8 kHz in addition to pure-tone average increased significantly; however, the change in DP-OAE results was not statistically significant at any frequency. The RIT dose had no effect on auditory function.
Conclusion:
In this study, we found some deleterious effects of RIT on audiometric thresholds, with no significant effect on DP-OAE results.