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NaviCom: a web application to create interactive molecular network portraits using multi-level omics data.

Mathurin Dorel1,2,3,4,5,6, Eric Viara7, Emmanuel Barillot1,2,3,4

  • 1Institut Curie, 26 rue d'Ulm, F-75005 Paris, France.

Database : the Journal of Biological Databases and Curation
|April 18, 2017
PubMed
Summary

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This summary is machine-generated.

NaviCom is a new tool that visualizes multi-level omics data on biological networks. It helps researchers understand cancer molecular portraits and generate hypotheses about deregulated mechanisms.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Cancer Research

Background:

  • High-throughput molecular technologies generate vast amounts of omics data for human diseases like cancer.
  • Analyzing multi-level omics data within biological network maps offers insights into molecular regulation patterns.
  • Existing resources like cBioPortal and NaviCell can be integrated for enhanced data exploration.

Purpose of the Study:

  • To develop NaviCom, a Python package and web platform, for visualizing multi-level omics data on biological network maps.
  • To bridge the gap between cancer omics data resources and network visualization tools.
  • To enable easy creation of interactive, network-based cancer molecular portraits for hypothesis generation.

Main Methods:

  • Developed NaviCom as a Python package and web platform.

Related Experiment Videos

  • Integrated NaviCom with cBioPortal for cancer omics data and NaviCell for network maps.
  • Implemented standardized data display modes for network-based visualization.
  • Utilized the Atlas of Cancer Signalling Network (ACSN) maps for illustration.

    • Main Results:

    • NaviCom facilitates the visualization of multi-level omics data on biological networks.
    • The platform enables users to create interactive cancer molecular portraits using various network maps.
    • NaviCom effectively bridges data from cBioPortal with visualization capabilities of NaviCell.

    Conclusions:

    • NaviCom simplifies the exploration of complex omics data in the context of biological networks.
    • The tool aids in formulating hypotheses regarding molecular mechanisms in diseases like cancer.
    • NaviCom provides a user-friendly interface for network-based analysis of cancer omics data.