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Automated Hydrophobic Interaction Chromatography Column Selection for Use in Protein Purification
Published on: September 21, 2011
A comparison of a novel robust decentralised control strategy and MPC for industrial high purity, high recovery,
Isuru A Udugama1, Florian Wolfenstetter2, Robert Kirkpatrick2
1Chemical & Materials Engineering, The University of Auckland, New Zealand; Industrial Information and Control Centre, The University of Auckland, New Zealand.
Abstract:
In this work we have developed a novel, robust practical control structure to regulate an industrial methanol distillation column. This proposed control scheme is based on a override control framework and can manage a non-key trace ethanol product impurity specification while maintaining high product recovery. For comparison purposes, a MPC with a discrete process model (based on step tests) was also developed and tested. The results from process disturbance testing shows that, both the MPC and the proposed controller were capable of maintaining both the trace level ethanol specification in the distillate (XD) and high product recovery (β). Closer analysis revealed that the MPC controller has a tighter XD control, while the proposed controller was tighter in β control. The tight XD control allowed the MPC to operate at a higher XD set point (closer to the 10ppm AA grade methanol standard), allowing for savings in energy usage. Despite the energy savings of the MPC, the proposed control scheme has lower installation and running costs. An economic analysis revealed a multitude of other external economic and plant design factors, that should be considered when making a decision between the two controllers. In general, we found relatively high energy costs favour MPC.
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