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Fatigue in multiple sclerosis - Insights into evaluation and management
Samar S Ayache1, Moussa A Chalah2
1EA 4391, excitabilité nerveuse et thérapeutique, université Paris-Est-Créteil, Créteil, France; Service de physiologie-explorations fonctionnelles, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris, 51, avenue de Lattre-de-Tassigny, 94010 Créteil, France; Neurology division, Lebanese American university medical center, Rizk hospital (LAUMC-RH), Beirut, Lebanon.
Neurophysiologie Clinique = Clinical Neurophysiology
|April 19, 2017
Summary
Multiple sclerosis (MS) fatigue is a common, distressing symptom with complex causes. This review explores its pathophysiology, assessment, and management, including noninvasive brain stimulation.
Area of Science:
- Neuroscience
- Neurology
- Immunology
Background:
- Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative central nervous system disease.
- Fatigue is a prevalent and distressing symptom in MS patients.
- The pathophysiology of MS fatigue is not fully understood, with multiple contributing factors.
Purpose of the Study:
- To review the definition and pathophysiology of MS fatigue.
- To examine clinical, structural, and functional correlates of MS fatigue.
- To discuss assessment tools and management strategies, including noninvasive brain stimulation.
Main Methods:
- Literature review of MS fatigue.
- Analysis of pathophysiological mechanisms.
- Evaluation of clinical assessments and therapeutic interventions.
Main Results:
- MS fatigue is multifactorial, influenced by sleep, endocrine, and mood disorders.
- Various assessment tools and management strategies exist.
- Noninvasive brain stimulation shows promise for MS fatigue.
Conclusions:
- MS fatigue requires comprehensive evaluation and tailored management.
- Understanding the complex pathophysiology is key to effective treatment.
- Further research into noninvasive brain stimulation is warranted.