Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normal and Neoplastic Stem Cells.

Melissa N McCracken1,2,3, Benson M George1,2,3, Kevin S Kao1,2

  • 1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305.

Cold Spring Harbor Symposia on Quantitative Biology
|April 19, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Patient-Derived Screen Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Immunotherapy Partners.

Cancer immunology research·2026
Same author

Isolation of postnatal human neural stem cells.

bioRxiv : the preprint server for biology·2026
Same author

Xenophagocytosis blockade enhances interspecies chimerism.

Cell·2026
Same author

Somatic mutations reveal the ontogeny of human microglia.

bioRxiv : the preprint server for biology·2026
Same author

Polyclonal regeneration of mouse bone marrow endothelial cells after irradiative conditioning.

Cell reports·2026
Same author

Electrical stimulation promotes longevity and regeneration in a colonial chordate.

Proceedings of the National Academy of Sciences of the United States of America·2026

This review highlights stem cell research, focusing on hematopoietic stem cells (HSCs) and leukemic stem cells. Discoveries have advanced bone marrow transplantation, cancer immunotherapy, and stem cell research.

Area of Science:

  • Stem cell biology
  • Cancer research
  • Hematology

Background:

  • Stem cells possess self-renewal and differentiation capabilities, crucial for development and tissue repair.
  • Understanding stemness regulation is vital for both normal development and diseases like cancer.
  • Our laboratory investigates embryonic, tissue-specific, and neoplastic stem cells.

Purpose of the Study:

  • To review our laboratory's contributions to understanding stem cells.
  • To highlight the identification of mouse hematopoietic stem cells (HSCs) and human leukemic stem cells.
  • To discuss the implications of this research for preclinical and clinical applications.

Main Methods:

  • Comparative analysis of embryonic, tissue-specific, and neoplastic stem cells.

Related Experiment Videos

  • Identification and characterization of mouse hematopoietic stem cells (HSCs).
  • Isolation and study of human leukemic stem cells.

    • Main Results:

    • Significant advancements in bone marrow transplantation protocols.
    • Development of a HSC reporter mouse model.
    • Progress in cancer immunotherapy through stem cell research.

    Conclusions:

    • Our research has provided critical insights into normal and neoplastic stem cell biology.
    • These findings have led to tangible improvements in clinical treatments and research tools.
    • Continued investigation will further elucidate stem cell properties, function, and regulation.