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Published on: July 11, 2013
Ezogabine skin discoloration is reversible after discontinuation
Sally V Mathias1, Bassel W Abou-Khalil1
1Vanderbilt University Medical Center, Department of Neurology- Epilepsy division, 1161 21st Ave South, Nashville, TN 37232, USA.
Abstract:
There is concern that bluish skin discoloration associated with ezogabine treatment could be permanent. We present a case of ezogabine-induced skin discoloration that resolved completely after discontinuation. A 55-year-old woman started ezogabine 400 mg three times a day at age 41. Bluish pigmentation over the toe nails, finger nails, around eyes and over and around lips was first noted after 5 years of treatment. Ezogabine was discontinued eight years after initiation. Skin discoloration improved within 6 months and completely resolved within 6 years of discontinuation. This case suggests that ezogabine-induced discoloration is reversible after discontinuation of treatment.
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