Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Paradigm for Detecting Silent Thoracic Aneurysm Disease.

John A Elefteriades1, Bulat A Ziganshin2

  • 1Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut.

Seminars in Thoracic and Cardiovascular Surgery
|April 19, 2017
PubMed
Summary

Thoracic aortic aneurysms (TAA) are often silent but deadly. Identifying associated conditions can help screen patients for TAA, preventing fatal complications like rupture or dissection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thromboexclusion Procedure for a Recurrent Descending Aortic Pseudoaneurysm in the Pre-Stent Era.

Annals of thoracic surgery short reports·2026
Same author

Thoracic Aortic Aneurysm and Giant Cell Arteritis: Clarifying the Link.

Aorta (Stamford, Conn.)·2025
Same author

Novel Aortic Root Measurement Technique Using the Laplace Diameter for Identifying Patients at Risk for Type A Dissection.

Annals of thoracic surgery short reports·2025
Same author

Thoracic aortic aneurysm.

Nature reviews. Disease primers·2025
Same author

Efficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials.

Vascular pharmacology·2025
Same author

Genetic Overlap of Thoracic Aortic Aneurysms and Intracranial Aneurysms.

Genes·2025

Area of Science:

  • Cardiovascular Medicine
  • Radiology
  • Genetics

Background:

  • Thoracic aortic aneurysms (TAA) present a significant diagnostic challenge due to their asymptomatic nature.
  • TAA complications, such as aortic rupture and dissection, carry high mortality rates.
  • Current TAA screening strategies lack proven cost-effectiveness, leading to incidental diagnoses.

Purpose of the Study:

  • To introduce the "Guilt by Association" paradigm for early TAA detection.
  • To highlight clinical markers associated with TAA to prompt timely screening.
  • To improve the identification of individuals at risk for thoracic aortic disease.

Main Methods:

  • Review of recent studies identifying clinical "associates" of TAA.
  • Analysis of established correlations between specific conditions and TAA presence.
Keywords:
early detectionguilt by associationthoracic aortic aneurysm

Related Experiment Videos

  • Proposal of a screening approach based on the "Guilt by Association" concept.

    • Main Results:

    • Several clinical markers are strongly associated with TAA, including intracranial aneurysm, bicuspid aortic valve, and a positive family history.
    • These associates, despite unclear underlying mechanisms, provide a basis for targeted TAA screening.
    • The "Guilt by Association" paradigm offers a novel strategy for detecting silent thoracic aortic disease.

    Conclusions:

    • Early detection of TAA is crucial for preventing life-threatening complications.
    • The "Guilt by Association" paradigm facilitates TAA screening by leveraging known associated conditions.
    • Identifying these clinical markers can lead to timely diagnosis and prophylactic treatment of TAA.