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Exercise Is Medicine, But Does It Interfere With Medicine?
Mackenzie McLaughlin1, Ira Jacobs
1Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, Ontario, Canada.
Exercise and Sport Sciences Reviews
|April 19, 2017
Summary
Regular exercise can alter how the body processes medications, impacting drug effectiveness and safety. This review explores how physical activity influences drug levels in the blood.
Area of Science:
- Pharmacology
- Exercise Physiology
- Sports Medicine
Background:
- Exercise is a common therapeutic intervention, often used alongside pharmacological treatments.
- Physiological adaptations to exercise significantly alter body composition and function.
- These exercise-induced changes can impact how the body handles drugs.
Purpose of the Study:
- To review existing research on the influence of exercise on drug pharmacokinetics.
- To highlight how exercise may affect drug absorption, distribution, metabolism, and excretion (ADME).
- To discuss the implications of exercise on drug efficacy and patient safety.
Main Methods:
- Literature review of studies investigating exercise and drug pharmacokinetics.
- Analysis of research examining acute and chronic exercise adaptations.
- Synthesis of findings related to drug plasma concentrations.
Main Results:
- Exercise can modify drug absorption and distribution.
- Metabolic and excretory processes for drugs are influenced by physical activity.
- Changes in drug plasma concentrations due to exercise have been observed across various studies.
Conclusions:
- Exercise is a significant factor affecting drug pharmacokinetics.
- Understanding these interactions is crucial for optimizing therapeutic outcomes.
- Further research is needed to fully elucidate exercise-drug interactions for improved patient care.