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Small Sample Sizes Confound Understanding of Cardiometabolic Responses to Exercise
Linda S Pescatello1, Lauren M L Corso, Hayley V MacDonald
11Departments of Kinesiology; 2Psychological Sciences; 3Statistics; 4Institute for Collaboration on Health, Intervention and Policy (InCHIP), University of Connecticut, Storrs CT; 5Department of Kinesiology, The University of Alabama, Tuscaloosa, AL; and 6Department of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford CT.
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Considerable variability exists in the cardiometabolic disease biomarker response to exercise. We propose that a major contributor to this heterogeneity is underpowered studies due to small sample sizes. To test our hypothesis, we conducted a systematic review to identify meta-analyses/reviews of randomized controlled trials (RCT) and RCT that examined the cardiometabolic disease biomarker response to aerobic and resistance exercise.