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Periodontitis changes renal structures by oxidative stress and lipid peroxidation
Luiz Felipe C França1, Any Carolina C G Vasconcelos1,2, Felipe R P da Silva1
1Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piauí, Parnaíba, PI, Brazil.
Journal of Clinical Periodontology
|April 19, 2017
Summary
Experimental periodontitis induces kidney tissue changes and oxidative stress, including brush border disruption. However, these effects did not significantly alter overall kidney function markers in rats.
Area of Science:
- Renal physiology
- Periodontal disease research
- Oxidative stress mechanisms
Background:
- Periodontitis is a common inflammatory condition affecting oral tissues.
- Emerging evidence suggests links between systemic diseases and periodontal health.
- The impact of periodontitis on renal tissue integrity and oxidative balance requires further investigation.
Purpose of the Study:
- To determine if experimental periodontitis alters renal tissue structure and induces oxidative stress.
- To assess histomorphometric and histopathological changes in kidney tissues.
- To evaluate key biomarkers of oxidative stress in renal tissues.
Main Methods:
- Twenty-two Wistar rats were divided into control and experimental periodontitis groups.
- Periodontal parameters (GBI, PPD, ABL) and renal histomorphometry were assessed.
- Renal oxidative stress markers (MDA, GSH) and kidney function biomarkers were analyzed.
Main Results:
- Periodontitis induced significant histomorphometric changes in renal corpuscles.
- Disruption of the renal tubule brush border was observed in the periodontitis group.
- The periodontitis group exhibited increased kidney MDA and decreased GSH levels.
Conclusions:
- Experimental periodontitis leads to renal tissue alterations and increased oxidative stress.
- Brush border integrity in renal tubules is compromised by periodontitis.
- Despite renal tissue changes, key renal function markers remained unaffected.