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Lisinopril: dose-peak effect relationship in essential hypertension
V J Cirillo1, H J Gomez, J Salonen
1Department of Cardiovascular Clinical Research, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065-0914.
British Journal of Clinical Pharmacology
|May 1, 1988
Summary
This study on lisinopril for hypertension found that higher doses (10-80 mg) provided greater blood pressure reduction than lower doses (2.5 mg). Initial 10 mg or 20 mg doses of lisinopril appear equally safe regarding symptomatic hypotension.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Clinical Trials
Background:
- Essential hypertension is a prevalent cardiovascular condition requiring effective pharmacotherapy.
- Understanding the dose-response relationship of antihypertensive drugs is crucial for optimizing treatment and minimizing adverse effects.
Purpose of the Study:
- To investigate the dose-peak effect relationship of lisinopril in patients with essential hypertension.
- To assess the antihypertensive efficacy and potential safety implications of different lisinopril dosages.
Main Methods:
- A double-blind, parallel study involving 83 patients with mild to moderate essential hypertension.
- Patients received placebo washout followed by randomized treatment with lisinopril at 2.5, 10, 20, or 80 mg once daily for one week.
Main Results:
- Lisinopril doses of 10 mg and 20 mg demonstrated comparable peak antihypertensive effects, exceeding that of 2.5 mg but less than 80 mg.
- The 24-hour post-drug antihypertensive response showed a dose-related increase across the 2.5 mg to 80 mg range.
- An initial lisinopril dose of 20 mg is suggested to carry a similar risk of first-dose symptomatic hypotension as a 10 mg dose.
Conclusions:
- Lisinopril exhibits a dose-dependent antihypertensive effect within the evaluated range (2.5-80 mg).
- The 10 mg and 20 mg doses offer significant antihypertensive benefits, with comparable peak effects and potentially similar safety profiles regarding initial hypotension.
- Higher doses of lisinopril provide a greater magnitude of blood pressure reduction at 24 hours.