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Quantitative depth-resolved microcirculation imaging with optical coherence tomography angiography (Part Ι): Blood
Wanrong Gao1,2
1Department of Optical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu, China.
Microcirculation (New York, N.Y. : 1994)
|April 19, 2017
Summary
Optical Coherence Tomography (OCT) angiography enables in vivo imaging of microvascular networks. This review covers OCT techniques for blood flow and vessel visualization, discussing limitations and clinical applications.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Microvascular network imaging is crucial for diagnosing and managing various diseases.
- Optical Coherence Tomography (OCT) angiography offers non-invasive visualization of blood flow.
- Understanding microcirculation dynamics is essential for clinical decision-making.
Purpose of the Study:
- To review phenomena explored in OCT for imaging microcirculation blood flow and vessels.
- To discuss parameters limiting accurate blood flow velocity measurements.
- To explore clinical applications and future developments of OCT flow imaging.
Main Methods:
- Review of established and emerging OCT angiography techniques.
- Analysis of physical principles governing OCT-based flow imaging.
- Discussion of factors affecting velocity measurement accuracy.
Main Results:
- OCT angiography allows depth-resolved imaging of blood flow vectors and microvessels.
- Various OCT phenomena have been investigated for enhanced flow visualization.
- Limitations in accurate velocity quantification are identified.
Conclusions:
- OCT angiography is a promising tool for in vivo microvascular imaging.
- Further development is needed to overcome current measurement limitations.
- Clinical applications in diagnosis and patient management are expanding.