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Related Experiment Videos

Update on Chemotherapy-Induced Peripheral Neuropathy.

Comana Cioroiu1, Louis H Weimer2

  • 1Neurological Institute of New York, Columbia University Medical Center, 710 W168th Street, New York, NY, 10032, USA.

Current Neurology and Neuroscience Reports
|April 20, 2017
PubMed
Summary

Chemotherapy-induced peripheral neuropathy (CIPN) is a significant side effect impacting patient quality of life. This review details current and emerging agents causing CIPN, emphasizing risk factors and clinical presentations.

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Area of Science:

  • Neuroscience
  • Oncology
  • Pharmacology

Background:

  • Chemotherapy-induced peripheral neuropathy (CIPN) is a common and often dose-limiting toxicity associated with cancer treatment.
  • The clinical significance of CIPN and its impact on patient quality of life are increasingly recognized.
  • Ongoing research focuses on identifying risk factors for CIPN to enable better patient stratification.

Purpose of the Study:

  • To review the most important and recent chemotherapeutic agents implicated in CIPN.
  • To examine the mechanisms, risk factors, and clinical patterns of CIPN.
  • To discuss novel and prospective drugs with CIPN-like effects that may be less familiar to neurologists.

Main Methods:

  • Literature review of recent chemotherapeutic agents and their association with peripheral neuropathy.
Keywords:
EribulinIxabepiloneLenalidomideNivolumabPembrolizumabProteasome inhibitorsTaxanes

Related Experiment Videos

  • Analysis of established and emerging drug classes known to cause CIPN.
  • Examination of clinical presentations and potential risk factors for CIPN.

    • Main Results:

    • Newer agent classes, including immune checkpoint inhibitors, monoclonal antibodies, immunomodulatory agents, and proteasome inhibitors, are implicated in CIPN.
    • Established drug classes such as taxanes, platins, and vinca alkaloids continue to be associated with CIPN.
    • CIPN presents with diverse clinical patterns and is a critical factor in chemotherapy dose limitation.

    Conclusions:

    • Understanding the mechanisms and risk factors for CIPN is crucial for developing preventive and therapeutic strategies.
    • Continued surveillance of novel and established agents is necessary to manage CIPN effectively.
    • Future research should prioritize elucidating toxicity mechanisms and improving management of chemotherapy-induced peripheral neuropathy.