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Pharmacokinetics, safety and tolerability of a novel tocopheryl phosphate mixture/oxycodone transdermal patch system:
Paul D Gavin1, Lee S Simon2, Thomas Schlagheck3
1Phosphagenics Limited, 11 Duerdin Street, Clayton VIC 3168, Australia.
Aim:
To characterize the pharmacokinetic profile and evaluate the safety and tolerability of a transdermal oxycodone patch containing tocopheryl phosphate mixture (TPM).
Patients & Methods:
Eleven healthy subjects received a single application of three TPM/oxycodone patches applied to the torso for 72 h.
Results:
Oxycodone was detected 8.0 ± 2.7-h postpatch administration, reaching a mean maximum plasma concentration of 3.41 ± 1.34 ng/ml at 49.3 ± 21.2 h. The safety profile was consistent with the application method and known side-effect profile of oxycodone and naltrexone. No treatment-limiting skin irritation was observed.
Conclusion:
A 3-day application of the TPM/oxycodone patch demonstrated an acceptable safety profile and was well tolerated by healthy subjects, with limited dermal irritation following application.
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