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Catalyst-free synthesis of novel dimeric β-carboline derivatives via an unexpected [2 + 2 + 2] annulation
Hai-Lei Cui1, Jing-Fang Wang, Hai-Lin Zhou
1International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing 402160, P.R. China. cuihailei616@163.com.
Organic & Biomolecular Chemistry
|April 20, 2017
Abstract:
We report here an unexpected catalyst-free [2 + 2 + 2] annulation reaction which allows access to novel complex dimeric β-carboline derivatives in a single step. Various substituted ynones could react with dihydro-β-carboline imines to deliver interesting [2 + 2 + 2] annulation products in moderate to good yields. Alkynoates can also be tolerated in this system.