[OPTIMIZATION OF REPARATIVE OSTEOGENESIS JAWS ON AGING (PRECLINICAL STUDIES)]

Area of Science:

• Regenerative medicine
• Oral and maxillofacial surgery
• Gerontology

Background:

• Aging significantly impairs bone healing and increases the risk of complications.
• Optimizing reparative osteogenesis in elderly patients is crucial for successful surgical outcomes.
• Peptide bioregulators offer a potential therapeutic approach to enhance tissue regeneration.

Purpose of the Study:

• To evaluate the efficacy of the peptide bioregulator Kartalaks in optimizing reparative osteogenesis in jaw bone defects in aged rats.
• To investigate the optimal timing for Kartalaks administration to enhance mandibular bone healing.

Main Methods:

• Pre-clinical study involving aged rats with surgically induced mandibular defects.
• Histological and morphometric analysis to assess bone regeneration.
• Comparison of Kartalaks administration before versus after surgery.

Main Results:

• Pre-operative administration of Kartalaks accelerated mandibular bone healing, achieving early-stage osteogenesis within 30 days.
• At 60-120 days, Kartalaks treatment resulted in a more advanced bone regenerate with reduced connective tissue and cartilage, and improved remodeling.
• Post-operative administration showed less significant improvements compared to pre-operative use.

Conclusions:

• Kartalaks, a peptide bioregulator, effectively optimizes reparative osteogenesis in aged rat mandibles.
• Pre-operative administration of Kartalaks is superior for enhancing bone healing and regeneration in elderly individuals.
• These findings support the potential of Kartalaks as a therapeutic agent for improving jaw bone repair in aging populations.