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Updated: Jun 25, 2026

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mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation

Olesya Chornoguz1,2,3,4, Robert S Hagan1,2,3,5, Azeb Haile1,2,3

  • 1Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.

Journal of Immunology (Baltimore, Md. : 1950)
|April 21, 2017
PubMed
Summary

Mice lacking Rheb, an mTORC1 activator, show reduced IFN-γ secretion due to impaired T-bet phosphorylation. This study identifies novel phosphorylation sites on T-bet regulated by mTORC1, impacting Th1 differentiation.

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