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High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

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Published on: September 2, 2009

Principle and basic property of the sequential flow pump.

Shintaro Hara¹, Erina Maeno², Xinyang Li²

¹Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-0033, Japan. hara@bme.gr.jp.

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs

|April 21, 2017

Summary

A novel sequential flow pump (SFP) offers a compact solution for extracorporeal membrane oxygenation (ECMO) systems. This innovative blood pump design achieves high performance, making portable ECMO a more viable option for critical care.

Keywords:

Blood pump Centrifugal pump ECMO Sequential flow pump

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Area of Science:

Biomedical Engineering
Cardiovascular Technology
Medical Devices

Background:

Acute heart and respiratory failure necessitate life support, often involving extracorporeal membrane oxygenation (ECMO).
Current ECMO systems can be bulky, limiting portability and accessibility in emergency care.
Development of compact and efficient blood pumps is crucial for advancing ECMO technology.

Purpose of the Study:

To introduce and evaluate a novel sequential flow-type centrifugal pump (SFP) for potential use in compact ECMO systems.
To investigate the principle and basic properties of the SFP using computational fluid dynamics (CFD) and experimental modeling.
To compare the performance of the SFP with conventional centrifugal pumps for ECMO applications.

Main Methods:

Computational fluid dynamic (CFD) analysis was performed on a computational model of the SFP.
An experimental model of the SFP was developed and tested to validate CFD results.
The SFP design features sequential centrifugal force application and a reversed port configuration for artificial lung integration.

Main Results:

CFD analysis demonstrated that the SFP achieves higher performance compared to a single pressurization model at equivalent impeller speeds.
Experimental results closely mirrored the CFD model's predictions, confirming the SFP's basic properties.
The SFP's unique design enables high-pressure output without requiring high impeller rotational speeds.

Conclusions:

The sequential flow pump (SFP) shows significant potential for enhancing the compactness and portability of ECMO systems.
The SFP's performance characteristics suggest it may be more suitable for next-generation, compact ECMO devices than traditional centrifugal pumps.
This novel blood pump design could facilitate wider application of ECMO in emergency and critical care settings.