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Related Experiment Video

Updated: Jul 11, 2026

Isolation of Retinal Pigment Epithelial Cells from Guinea Pig Eyes

Isolation of Retinal Pigment Epithelial Cells from Guinea Pig Eyes

Published on: May 9, 2023

Age-related decline in retinal function in marmosets.

Takahiko Noro^1,2,3, Xiaoli Guo¹, Rika Kikuchi²

¹Visual Research Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.

Scientific Reports

|July 2, 2025

Summary

Aging causes vision decline, impacting quality of life. Marmosets show age-related retinal changes and increased oxidative stress, offering a promising model for studying age-related vision loss.

Keywords:

Age-related retinal degeneration Marmosets Oxidative stress

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Author Spotlight: Marmoset Research - Scope and Challenges

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Last Updated: Jul 11, 2026

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Author Spotlight: Marmoset Research - Scope and Challenges

Author Spotlight: Marmoset Research - Scope and Challenges

Published on: June 9, 2023

Area of Science:

Ophthalmology
Gerontology
Primate Research

Background:

Age-related vision deterioration significantly impacts quality of life globally.
Rodent models present translational challenges in aging research due to anatomical and genetic differences from humans.

Purpose of the Study:

To investigate age-related changes in marmoset eyes non-invasively.
To evaluate marmosets as a translational model for age-related vision decline.

Main Methods:

Non-invasive examination of aged marmoset eyes.
Assessment of retinal structure and function.
Measurement of oxidative stress biomarker 4-HNE in serum.

Main Results:

Aged marmosets exhibited deteriorated retinal response and structure.
The peripheral retina was more susceptible to aging effects.
Increased serum 4-hydroxynonenal (4-HNE) levels were observed in aged marmosets, without correlation to retinal thickness.

Conclusions:

Marmosets display age-related vision changes mirroring human conditions.
Marmosets represent a valuable translational model for studying age-related vision decline and potential interventions.