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Cardiokines as Modulators of Stress-Induced Cardiac Disorders

Anna Planavila1, Joaquim Fernández-Solà2, Francesc Villarroya1

  • 1Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Barcelona, Spain.

Advances in Protein Chemistry and Structural Biology
|April 22, 2017
PubMed

Insights

Newly identified heart-secreted proteins, cardiokines, regulate blood pressure and volume. This review explores emerging cardiokines in stress-induced heart diseases and their potential as diagnostic biomarkers.

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • Atrial natriuretic peptide, a heart-secreted hormone, regulates blood pressure and volume.
  • Cardiokines are emerging factors involved in interorgan and intercellular communication within the heart.

Purpose of the Study:

  • To review the roles of newly identified cardiokines in stress-induced cardiac diseases.
  • To discuss the potential of cardiokines as clinical biomarkers for cardiac disorders.

Main Methods:

  • Literature review of emerging cardiokines.
  • Analysis of cardiokine roles in cardiac pathophysiology.
  • Evaluation of cardiokines as diagnostic and prognostic markers.

Main Results:

  • Cardiokines coordinate interorgan communication and act in autocrine/paracrine manners within the myocardium.
  • Emerging cardiokines are primarily elevated in stress-induced cardiac conditions.

Conclusions:

  • Cardiokines represent a crucial signaling network in cardiovascular homeostasis.
  • Emerging cardiokines hold promise as novel biomarkers for diagnosing and predicting cardiac disease outcomes.

Keywords:
CardiokineInflammationRemodelingStress

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