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Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
Published on: November 15, 2024
Ethanolamine Metabolism in the Mammalian Gastrointestinal Tract: Mechanisms, Patterns, and Importance
1Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan 410125. China.
Abstract:
Nutritional exchanges and cooperation between bacteria in the gastrointestinal tract and the mammalian host play an important role in health and disease. Ethanolamine is an essential dietary lipid nutrient for animals and is abundant in both intestinal and bacterial cell membranes. Ethanolamine can be utilized by intestinal eukaryotic cells via the cytidine phosphoethanolamine pathway for de novo synthesis of phosphatidylethanolamine, and certain bacteria are able to catabolize it as a major carbon and/or nitrogen source with the help of ethanolamine utilization proteins. In addition, ethanolamine utilization dramatically affects lipid metabolism and short-chain fatty acid biosynthesis. Ethanolamine metabolism plays a significant role in the renewal and proliferation of intestinal cells and intestinal inflammation, and ethanolamine may be a nutritional target to diagnose or treat diseases such as inflammatory bowel disease. This review summarizes the mechanisms of ethanolamine metabolism in the mammalian gastrointestinal tract and its influence on intestinal health and immunity, thus providing a theoretical reference for further studies on mammalian nutrition and disease.
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