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Published on: May 21, 2015
[Association between root abnormalities and related pathogenic genes in patients with generalized aggressive
1Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
Genetic variations in vitamin D receptor (VDR) and Calcitonin Receptor (CTR) genes are linked to abnormal root morphology in aggressive periodontitis patients. Further research is needed to confirm these findings.
Area of Science:
- Periodontology
- Dental Genetics
- Bone Metabolism
Background:
- Generalized aggressive periodontitis (GAgP) is a severe form of gum disease.
- Abnormal root morphology can influence tooth prognosis and treatment outcomes.
- Gene polymorphisms related to bone metabolism and root development may play a role in GAgP.
Purpose of the Study:
- To investigate the association between abnormal root morphology and gene polymorphisms in patients with GAgP.
- To explore the relationship between root development and bone metabolism-related gene variations in GAgP.
Main Methods:
- 179 GAgP patients were analyzed for abnormal root morphology using periapical radiographs.
- Thirteen single nucleotide polymorphisms (SNPs) in nine genes related to bone metabolism and root development were genotyped using MALDI-TOF-MS.
- Statistical analysis was performed to compare the incidence of abnormal root morphology across different genotypes.
Main Results:
- The overall incidence of root abnormality in GAgP patients was 14.49%.
- Significant differences in the number of teeth with abnormal root morphology were observed between genotypes of VDR rs2228570 (TT vs. CC) and CTR rs2283002 (CC vs. CT/TT).
- The CC genotype of CTR rs2283002 was associated with a significantly higher incidence of root morphological abnormalities.
Conclusions:
- Specific gene polymorphisms, namely VDR rs2228570 and CTR rs2283002, show a potential association with abnormal root morphology in GAgP.
- These findings suggest a genetic component influencing root development in the context of aggressive periodontitis.
- Further research is warranted to elucidate the precise mechanisms and clinical implications.
