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Related Concept Videos

Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

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Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
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Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
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Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

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Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
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Structure of Lipids

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Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
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Lipid Absorption

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Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
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Related Experiment Videos

Triglycerides Revisited to the Serial.

Paulo Ricardo Nazário Viecili1, Brenda da Silva2, Gabriela E Hirsch3

  • 1Grupo Interdisciplinar de Saúde (GIS), Centro de Ensino e Pesquisa do Instituto de Cardiologia de Cruz Alta (CEP-ICCA), Cruz Alta, Brazil; Programa de Residência Médica do Hospital São Vicente de Paulo (HSVP), Cruz Alta, Brazil.

Advances in Clinical Chemistry
|April 23, 2017
PubMed
Summary
This summary is machine-generated.

Triglycerides (TGs) play a complex role in cardiovascular health and disease. While their use as biomarkers is debated, high triglycerides are increasingly linked to inflammation, cardiovascular events, and mortality.

Keywords:
AtherosclerosisBiomarkersCoronary artery diseaseHypertriglyceridemiaTreatment

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Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Genetics

Background:

  • Triglycerides (TGs) are integral to cardiovascular system function.
  • Dysregulation of TGs contributes to cardiovascular disease (CVD) development and clinical presentation.

Purpose of the Study:

  • To review the multifaceted role of triglycerides in cardiovascular health and disease.
  • To explore TG regulation, biomarker potential, and therapeutic strategies.
  • To synthesize current literature for improved understanding.

Main Methods:

  • Comprehensive literature search focusing on recent publications (last 5 years).
  • Analysis of enzymatic and genetic regulation of TGs.
  • Evaluation of TG relevance as preclinical and clinical biomarkers.
  • Review of current and emerging TG-lowering treatments.

Main Results:

  • Evidence regarding TGs as definitive disease biomarkers remains inconclusive.
  • Growing evidence supports a significant role for hypertriglyceridemia in atherosclerotic inflammation.
  • Hypertriglyceridemia is increasingly associated with adverse cardiovascular outcomes and mortality.

Conclusions:

  • Triglyceride management is crucial in cardiovascular disease prevention.
  • Further research is needed to clarify the precise role of TGs as biomarkers.
  • Emerging therapies offer new avenues for managing hypertriglyceridemia and its cardiovascular impact.