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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
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Modeling human infertility with pluripotent stem cells.

Di Chen1, Joanna J Gell2, Yu Tao1

  • 1Department of Molecular, Cell and Developmental Biology, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Los Angeles, CA 90095, USA; University of California, Los Angeles, Los Angeles, CA 90095, USA.

Stem Cell Research
|April 23, 2017
PubMed
Summary
This summary is machine-generated.

Human fertility relies on germline development. Pluripotent stem cells reveal distinct human germline mechanisms compared to rodents, advancing fertility research.

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Area of Science:

  • Reproductive biology and developmental science.
  • Human embryology and stem cell research.

Background:

  • Human fertility depends on germline establishment and differentiation.
  • Germline cells (gametes) transmit genetic and epigenetic information across generations.
  • Early germline specification occurs during embryonic gastrulation.

Purpose of the Study:

  • To discuss key molecular pathways in human germline differentiation.
  • To highlight how pluripotent stem cells advance the study of early human germline specification.
  • To understand the basis of human fertility.

Main Methods:

  • Utilizing next-generation sequencing (NGS) for genetic analysis.
  • Employing gene editing technologies for mechanistic studies.
  • Differentiating germline cells from human pluripotent stem cells (hPSCs).

Main Results:

  • Core molecular mechanisms of human germline development differ from rodents.
  • Pluripotent stem cells provide a novel model for studying human germline specification.
  • Advancements in sequencing and gene editing enable detailed investigation.

Conclusions:

  • Human germline development possesses unique molecular underpinnings.
  • Pluripotent stem cell models are crucial for understanding human fertility.
  • Research is shifting from rodent models to human-specific studies.