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An acetone-based phantom for quantitative diffusion MRI.

Xiaoke Wang1,2, Scott B Reeder1,2,3,4,5, Diego Hernando1,3

  • 1Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA.

Journal of Magnetic Resonance Imaging : JMRI
|April 23, 2017
PubMed
Summary
This summary is machine-generated.

A new acetone-D2O phantom offers a wider range of apparent diffusion coefficient (ADC) values for quantitative diffusion MRI compared to water-based phantoms. This advancement enhances MRI capabilities for precise measurements.

Keywords:
D2Oacetoneapparent diffusion coefficient (ADC)phantompolyvinylpyrrolidone (PVP)quantitative diffusion MRI

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Diffusion MRI
  • Phantom Development

Background:

  • Quantitative diffusion MRI requires phantoms with tunable apparent diffusion coefficient (ADC) properties.
  • Existing water-based phantoms have limitations in their ADC range, particularly at low temperatures.
  • Developing novel phantoms is crucial for advancing MRI accuracy and applications.

Purpose of the Study:

  • To propose and evaluate an acetone-D2O phantom for quantitative diffusion MRI.
  • To assess the phantom's extended apparent diffusion coefficient (ADC) range.
  • To compare the acetone-D2O phantom's properties with existing water-based phantoms.

Main Methods:

  • Constructed acetone-D2O, sucrose water, and PVP water phantoms at various concentrations (0-50%).
  • Evaluated phantoms at 1.5T using diffusion-weighted MR spectroscopy (DW-MRS) and diffusion-weighted echo-planar imaging (DW-EPI).
  • Assessed MR spectra, diffusion signal decay, ADC tunability, and ADC range.

Main Results:

  • All phantoms exhibited desirable signal properties and tunable ADC when cooled in an ice-water bath.
  • Water-based phantoms had a limited ADC range (0.2-1.1·10^-3 mm²/s) at 0°C.
  • The proposed acetone-D2O phantom demonstrated a significantly wider ADC range (0.6-3.5·10^-3 mm²/s) at 0°C.

Conclusions:

  • The acetone-D2O phantom provides desirable signal characteristics over an extended ADC range.
  • Temperature control via an ice-water bath is effective for the acetone-D2O phantom.
  • This novel phantom enhances the capabilities of quantitative diffusion MRI.