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Upper extremity deep venous thrombosis and stenosis after implantation of pacemakers and defibrillators; A
Insights
Venous obstruction after cardiac device implantation is common, particularly with multiple leads. Pacemaker and implantable cardioverter-defibrillator leads pose similar risks for this complication.
Area of Science:
- Cardiology
- Medical Devices
- Vascular Medicine
Background:
- Venous obstruction is a frequent complication after cardiac pacemaker and defibrillator implantation.
- The precise incidence and risk factors for venous obstruction remain largely unknown.
Purpose of the Study:
- To determine the incidence of venous obstruction following cardiac device implantation.
- To analyze the contribution of individual risk factors to venous obstruction.
Main Methods:
- 57 patients undergoing first-time transvenous pacemaker, implantable cardioverter-defibrillator (ICD), or cardiac resynchronization therapy device implantation were enrolled.
- Peripheral arm venography was performed post-implantation and again at 3-6 months follow-up.
Main Results:
- 21% of 42 completing patients showed significant venous obstruction (>50%) at follow-up.
- Increased lead number (2.56 vs 1.58) was significantly associated with obstruction (P=0.001).
- Cardiac resynchronization therapy patients had higher obstruction rates (P=0.01); multivariate analysis identified total lead number as a positive predictor (OR: 19.2, P=0.015).
Conclusions:
- Venous obstruction is a relatively frequent complication after pacemaker or ICD implantation.
- Pacemaker and ICD leads present similar risks for venous obstruction.
- Patients with multiple leads have an increased risk of venous obstruction.
Background:
Obstruction of the access vein following cardiac pacemaker and defibrillator implantation is a common complication. However, the exact incidence and contributing risk factors are unknown. The aim of this study is to determine the incidence and analyze the contribution of each risk factor.
Methods:
57 consecutive patients candidate for their first transvenous pacemaker, implantable cardioverter-defibrillator (ICD), or cardiac resynchronization therapy device implantation were enrolled. After implantation, venography of the ipsilateral peripheral arm was performed. Patients underwent their second venography after the follow-up period of 3 to 6 months.
Results:
42 patients (13 females, mean age 59.71 ± 12.33) completed the study. The followup venography showed significant venous obstruction (more than 50%) in 9 (21%) patients, but in none of the individuals, venography revealed total occlusion of the veins. Patients with obstruction had more leads in their veins (2.56 ± 0.53 vs 1.58 ± 0.71, P = 0.001). Venous obstruction was significantly more prevalent in patients with implanted cardiac resynchronization therapy device compared with an ICD or pacemaker (p = 0. 01). Age, gender, diabetes mellitus, hypertension, ischemic heart disease and antiplatelet consumption did not reveal any other contribution to the risk of thrombosis. In multivariate analysis, total lead number was a positive predictor for venous occlusion (P = 0.015, OR:19.2, and CI: 1.7-207.1).
Conclusion:
Venous obstruction is relatively frequent after pacemaker or ICD implantation. This study also shows that pacemaker and ICD leads have a similar risk for lead-related venous obstruction. However, patients with multiple leads are associated with an increased risk.
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