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Cross-reaction between aromatic isocyanates (TDI and MDI): a specific bronchial provocation test study
A Innocenti1, A M Cirla, G Pisati
1Institute of Occupational Health, University of Siena, Italy.
Clinical Allergy
|July 1, 1988
Summary
Workers exposed to toluene diisocyanate (TDI) varnishes developed asthma. A study found a partial cross-response to methylene diphenyl diisocyanate (MDI) in 48% of cases, suggesting reaction patterns influence cross-reactivity.
Area of Science:
- Occupational Health
- Immunology
- Pulmonology
Background:
- Workers exposed to toluene diisocyanate (TDI)-catalyzed polyurethane varnishes can develop occupational asthma.
- TDI is a common sensitizer, leading to respiratory issues in exposed individuals.
Purpose of the Study:
- To investigate the potential for cross-respiratory responses between toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI) in workers with TDI-induced asthma.
- To explore if the pattern of asthmatic reaction to TDI influences cross-reactivity to other isocyanates.
Main Methods:
- Bronchial provocation tests (BPT) were used to assess asthmatic workers.
- Twenty-five workers with established TDI-induced asthma were tested for cross-response to MDI.
Main Results:
- A cross-response to MDI was observed in 48% of the workers tested.
- Cross-responders were more prevalent in subjects exhibiting a dual asthmatic reaction to TDI (P = 0.0334) compared to those with a late reaction (P = 0.0038).
Conclusions:
- A partial cross-reactivity exists between TDI and MDI in a subset of workers with occupational asthma.
- The specific pattern of asthmatic response to TDI may predict the likelihood of cross-reactivity to other isocyanates like MDI.