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Related Concept Videos

Biofilms01:29

Biofilms

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Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
190

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Related Experiment Video

Updated: Aug 19, 2025

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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PLA and PBAT-Based Electrospun Fibers Functionalized with Antibacterial Bio-Based Polymers.

A Chiloeches1,2, R Fernández-García3, M Fernández-García1,4

  • 1Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/ Juan de la Cierva 3, Madrid, 28006, Spain.

Macromolecular Bioscience
|November 28, 2022
PubMed
Summary
This summary is machine-generated.

Biodegradable antimicrobial fibers were created using poly(lactic acid) and poly(butylene adipate-co-terephthalate) with polyitaconate. These cationic fibers show significant antibacterial activity and minimal cytotoxicity, offering potential for biomedical applications.

Keywords:
antimicrobial fiberscell viabilitycytostatic effectelectrospinningpoly(lactic) acid

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Antimicrobial Technology

Background:

  • Development of advanced antimicrobial materials is crucial for combating infections.
  • Biodegradable polymers like PLA and PBAT offer sustainable alternatives for biomedical applications.
  • Functionalization of polymer surfaces can impart specific biological activities.

Purpose of the Study:

  • To create novel antimicrobial fibers using biodegradable polymers.
  • To investigate the effect of cationic azolium groups on antibacterial activity.
  • To evaluate the biocompatibility of the developed antimicrobial fibers.

Main Methods:

  • Electrospinning of poly(lactic acid) (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) blends.
  • Incorporation of polyitaconate containing azole groups (PTTI) into the polymer matrix.
  • Surface functionalization via N-alkylation to create cationic azolium groups.
  • Characterization of fiber properties (charge density, roughness, wettability) and antibacterial efficacy.
  • Assessment of fibroblast adhesion, morphology, and viability for biocompatibility.

Main Results:

  • Uniform, bead-free antimicrobial fibers were successfully fabricated.
  • Cationic functionalization significantly enhanced antibacterial activity against S. aureus and MRSA.
  • Fiber properties like charge density and hydrophobicity influenced antimicrobial performance.
  • No cytotoxic effect was observed, but a cytostatic effect on fibroblasts was noted due to electrostatic interactions.

Conclusions:

  • Quaternized PLA/PTTI fibers demonstrate potent antimicrobial properties.
  • The developed fibers show promise for applications requiring antibacterial surfaces.
  • Further research is needed to mitigate the cytostatic effect for enhanced biocompatibility.