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Updated: Mar 3, 2026

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
Published on: August 11, 2018
Antimicrobial peptides: Role in human disease and potential as immunotherapies
César de la Fuente-Núñez1, Osmar N Silva2, Timothy K Lu1
1Synthetic Biology Group, MIT Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA, United States; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, United States; Department of Biological Engineering, and Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States; Broad Institute of MIT and Harvard, Cambridge, MA, United States; Harvard Biophysics Program, Harvard University, Boston, MA, United States; The Center for Microbiome Informatics and Therapeutics, Cambridge, MA, United States.
Abstract:
Antimicrobial peptides (AMPs) have evolved through billions of years as part of our innate immune system. These agents are produced by various cells throughout the human body and play important roles in our ability to respond to infections. In this review, we outline evidence linking AMP expression with a range of inflammatory and autoimmune human diseases. Finally, we highlight the promise of endogenous AMP induction for the treatment of disease (i.e., host-directed therapy) and briefly mention the different peptide drugs that are currently undergoing clinical trials.
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