First clinical experiences with a novel endoscopic over-the-scope clip system

Area of Science:

• Gastroenterology
• Endoscopic Surgery

Background:

• Gastrointestinal (GI) fistulas, perforations, and post-polypectomy bleeding present significant clinical challenges.
• Endoscopic full-thickness resection (EFTR) is an emerging technique for managing certain GI lesions.

Purpose of the Study:

• To evaluate the safety and efficacy of the novel Padlock Clip (over-the-scope clip system) in treating GI conditions.
• To assess the utility of the Padlock Clip in performing EFTR.

Main Methods:

• The Padlock Clip system was used in 14 patients for various GI interventions.
• Eight patients were treated for GI fistulas, perforations, or bleeding.
• Six patients underwent EFTR using the Padlock Clip.

Main Results:

• Successful clip delivery was achieved in 7 of 8 patients for closure/hemostasis, with all achieving clinical success.
• Complete intestinal wall resection was achieved in 50% of EFTR cases, with R0 resection in 83.3%.
• No procedure-related complications or endoscopic recurrence were observed.

Conclusions:

• The Padlock Clip system demonstrates potential as a safe and effective tool for managing GI fistulas, perforations, and bleeding.
• The Padlock Clip is a viable option for performing EFTR with favorable resection and safety outcomes.