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Chemotherapy After Colonic Stent in Patients With Unresectable Obstructive Colorectal Cancer: A Retrospective
Akihisa Matsuda1, Norihiro Hanabata2, Yorinobu Sumida3
1Department of Gastroenterological SurgeryNippon Medical SchoolBunkyoTokyoJapan.
Endoscopy International Open
|August 13, 2026
Summary
Systemic chemotherapy following self-expandable metallic stent (SEMS) placement for obstructive colorectal cancer is feasible but carries risks. Complications like perforation and stent migration require vigilance, though survival outcomes may improve with primary tumor resection.
Area of Science:
- Gastroenterology
- Oncology
- Medical Devices
Background:
- Self-expandable metallic stents (SEMS) are standard for obstructive colorectal cancer.
- The safety and efficacy of subsequent systemic chemotherapy are not well-established.
Purpose of the Study:
- To investigate SEMS-related complications.
- To evaluate clinical outcomes of chemotherapy in patients with unresectable obstructive colorectal cancer.
Main Methods:
- Multicenter retrospective cohort study in Japan.
- Included 289 patients with unresectable obstructive colorectal cancer.
- Analyzed SEMS complications and chemotherapy outcomes.
Main Results:
- 30.1% experienced SEMS-related complications (perforation, re-obstruction, migration).
- Median progression-free survival was 9.2 months; median overall survival was 17.3 months.
- Primary tumor resection correlated with better survival but requires cautious interpretation.
Conclusions:
- Chemotherapy after SEMS placement is generally feasible.
- Clinicians must monitor for complications like perforation, migration, and re-obstruction.
- Further research is needed to optimize treatment strategies.
