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Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

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Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

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Related Experiment Video

Updated: Jul 4, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Rethinking Perioperative Corticosteroids in Esophageal Cancer Surgery: Evidence From an Integrative Meta-Analysis.

Tomohiko Yasuda1, Akihisa Matsuda2, Nobutoshi Hagiwara2

  • 1Department of Gastroenterological Surgery Nippon Medical School Chiba Hokusoh Hospital Chiba Japan.

Annals of Gastroenterological Surgery
|July 3, 2026
PubMed
Summary

Perioperative corticosteroids may reduce pneumonia, in-hospital mortality, and respiratory failure after esophagectomy. This meta-analysis found no increased risk of anastomotic leakage or adverse long-term survival outcomes.

Keywords:
esophageal neoplasmsesophagectomyglucocorticoidsperioperative carepostoperative complications

Related Experiment Videos

Last Updated: Jul 4, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

Area of Science:

  • Oncology
  • Surgery
  • Pharmacology

Background:

  • Esophagectomy is a high-risk surgery with significant postoperative complications.
  • Pulmonary issues, anastomotic leaks, and mortality are key concerns.
  • Corticosteroid use is debated due to inconsistent evidence on outcomes.

Purpose of the Study:

  • To evaluate the impact of perioperative corticosteroids on short-term complications and long-term survival in esophagectomy patients.
  • To synthesize existing evidence through a comprehensive meta-analysis.

Main Methods:

  • Systematic literature search of RCTs and observational studies up to October 2025.
  • Primary outcomes: pneumonia, anastomotic leakage, in-hospital mortality.
  • Secondary outcomes: various complications and overall survival; analyzed using random-effects models.

Main Results:

  • Corticosteroids significantly reduced pneumonia (OR=0.71), in-hospital mortality (OR=0.79), and respiratory failure (OR=0.30).
  • No increased rates of anastomotic leakage or wound infection were observed.
  • Long-term survival (HR=0.85) and other complications were not adversely affected.

Conclusions:

  • Perioperative corticosteroids may decrease major postoperative complications in esophagectomy.
  • No evidence of negative long-term oncologic outcomes was found.
  • Findings were primarily influenced by observational studies, warranting cautious interpretation.