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Cytotoxic flavonoids from the fruits of Derris indica
Chalotorn Saraphon1, Kampeebhorn Boonloh2, Veerapol Kukongviriyapan2
1a Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Faculty of Science, Department of Chemistry , Khon Kaen University , Khon Kaen 40002 , Thailand.
Abstract:
Chemical investigation of the ethyl acetate extract from the fruits of Derris indica has led to the isolation of a new furanoflavonoid derivative, 4'-hydroxypinnatin (1), and five known compounds. Pinnatin (2) showed strong cytotoxicity against cholangiocarcinoma (KKU-100) and human hepatoma (HepG2) cell lines with IC50 values of 6.0 ± 2.7 and 9.0 ± 4.1 μg/ml, respectively, and showed maximal cell killing effect of about 88-90%. Flavone 5 exhibited the most cytotoxicity against KKU-100 but it showed moderate efficacy (Emax = 50.7%).
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