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Bony demineralization following urinary intestinal diversion
W S McDougal1, M O Koch, C Shands
1Department of Urology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
The Journal of Urology
|October 1, 1988
Summary
Urinary intestinal diversion in rats led to decreased bone calcium. Supplementing with sodium bicarbonate or ascorbic acid prevented this bone demineralization, suggesting a way to maintain bone health.
Area of Science:
- Biochemistry
- Nephrology
- Orthopedics
Background:
- Urinary intestinal diversion is a surgical procedure with potential metabolic consequences.
- Bone mineral metabolism is crucial for skeletal integrity.
- Acidosis can negatively impact bone health.
Purpose of the Study:
- To investigate the impact of urinary intestinal diversion on bone mineral metabolism in a rat model.
- To assess the efficacy of sodium bicarbonate and ascorbic acid supplementation in mitigating these effects.
Main Methods:
- 78 rats underwent either sham operation or urinary intestinal diversion.
- Diverted rats received no supplement, sodium bicarbonate, or ascorbic acid for eight months.
- Bone mineral content and density were measured using dual photon densitometry.
Main Results:
- Urinary intestinal diversion caused minimal systemic acidosis and minor renal function changes.
- A significant decrease in bone calcium content was observed in diverted rats.
- Oral administration of sodium bicarbonate and ascorbic acid effectively prevented bone demineralization.
Conclusions:
- Urinary intestinal diversion adversely affects bone calcium content in rats.
- Sodium bicarbonate and ascorbic acid supplementation can counteract the negative effects on bone mineral metabolism.
- These findings highlight the importance of metabolic management following urinary intestinal diversion.