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First Two Imported Cases of Zika Virus Infections in Romania

Simin Aysel Florescu1,2, Ani Ioana Cotar3, Corneliu Petru Popescu2,4

  • 11 Infectious and Tropical Diseases Department, Carol Davila University of Medicine and Pharmacy , Bucharest, Romania .

Vector Borne and Zoonotic Diseases (Larchmont, N.Y.)
|April 25, 2017
PubMed

Insights

Two Romanian patients were diagnosed with imported Zika virus (ZIKV) infection. One case presented classically, while the other showed secondary ZIKV infection in a child vaccinated against yellow fever.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Zika virus (ZIKV) poses a global health threat, particularly in regions with ongoing outbreaks.
  • Imported cases highlight the importance of surveillance and diagnostics in non-endemic areas.
  • Yellow fever vaccination status can influence flaviviral infection patterns.

Observation:

  • Two imported Zika virus cases were identified in Romanian patients returning from endemic zones.
  • The first case exhibited a typical acute flaviviral infection presentation.
  • The second case involved a child, vaccinated against yellow fever, presenting with a secondary ZIKV infection.

Findings:

  • The study details two distinct clinical presentations of imported Zika virus infection.
  • Laboratory diagnostics for ZIKV presented challenges in both cases.
  • The second case suggests potential complexities in flaviviral co-infections or secondary infections in vaccinated individuals.

Implications:

  • These cases underscore the need for robust diagnostic capabilities for Zika virus in Romania.
  • Understanding atypical presentations is crucial for accurate diagnosis and patient management.
  • Further research is warranted on the impact of prior flaviviral vaccinations on ZIKV infection dynamics.
Keywords:
Zika virusflavivirusesmolecular diagnosisserologytravel

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