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Stage IV colorectal cancer primary site and patterns of distant metastasis
Jamaica R Robinson1, Polly A Newcomb1, Sheetal Hardikar1
1Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle WA, 98109, USA; Department of Epidemiology, University of Washington, 1959 NE Pacific St., Health Sciences Building, F-262, Seattle, WA, 98195, USA.
Background:
Although colorectal cancer (CRC) usually metastasizes to the liver and/or lungs, factors influencing the anatomic pattern of metastases remain poorly understood.
Methods:
We assessed the relationship between primary CRC site and pattern of synchronous metastasis among 1202 individuals diagnosed with incident metastatic CRC between 2010 and 2014 and identified through the Seattle-Puget Sound Surveillance, Epidemiology, and End Results (SEER) registry. Polytomous logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between primary tumor site and synchronous metastatic pattern.
Results:
Compared to patients with proximal colon primaries, patients with rectal primaries were more likely to present with lungs-only or liver and lungs metastases versus liver-only metastases (ORlungs-onlyvs.liver-only: 2.39, 95% CI: 1.35-4.24, ORliver+lungsvs.liver-only: 2.20, 95% CI: 1.46-3.32).
Conclusion:
These findings suggest that patients with rectal primaries are more likely than patients with colon primaries to present with synchronous lung metastases.
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